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Zenegra 100 is a medication used to treat erectile dysfunction, containing sildenafil citrate, which is also the active ingredient in Viagra. Like any medication, Zenegra 100 has contraindications and precautions that should be considered before use. Here are some general contraindications for using Zenegra 100:

Nitrates: Concomitant use of Zenegra 100 with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated. This combination can lead to a severe drop in blood pressure, which can be dangerous.

Hypersensitivity: Individuals with a known hypersensitivity or allergy to sildenafil or any other ingredient in Zenegra 100 should not use this medication.

Cardiovascular conditions: Zenegra 100 should be used with caution in individuals with cardiovascular diseases such as heart failure, coronary artery disease, or those who have recently experienced a heart attack or stroke. It's important to consult with a healthcare provider before using Zenegra 100 in such cases.

Liver or kidney impairment: Patients with severe liver or kidney impairment may require dosage adjustments or should avoid using Zenegra 100 altogether. It's important to consult with a healthcare provider for proper dosage adjustments.