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Malegra FXT Plus, which combines Sildenafil Citrate (100 mg) and Fluoxetine (60 mg), is primarily prescribed for treating erectile dysfunction (ED) and premature ejaculation (PE). However, its components are sometimes used off-label to manage other conditions due to their individual pharmacological effects.

Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is commonly used to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), and panic disorders. Its inclusion in Malegra FXT Plus helps manage PE by delaying ejaculation, but some doctors may recommend it off-label to support mood regulation, performance anxiety, or stress-related sexual dysfunction, especially when psychological issues contribute to ED or PE.

Sildenafil, known for treating ED, is also prescribed off-label for pulmonary arterial hypertension (PAH) because of its ability to relax blood vessels and lower blood pressure in the lungs.

Together, these drugs may be used off-label when both sexual performance and psychological symptoms are interlinked, particularly in men dealing with stress-related or anxiety-induced sexual issues.

Malegra FXT Plus may be used off-label due to the broader therapeutic effects of its ingredients, especially in cases where psychological and physical conditions overlap, but this should always be under strict medical supervision.