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Tadaflo 5 mg, which contains tadalafil, is commonly prescribed for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). However, certain health conditions can make its treatment less effective or increase the risk of side effects. These include: Severe Heart or Cardiovascular Conditions: Low blood pressure (hypotension): Tadalafil can cause a further drop in blood pressure, which could be dangerous for individuals already experiencing low blood pressure. Recent heart attack or stroke: If someone has had a heart attack or stroke within the past 6 months, using tadalafil may increase the risk of further complications. Severe heart failure: People with severe heart failure may have difficulty managing the additional stress on the cardiovascular system from tadalafil. Liver Problems: Liver disease: Conditions like cirrhosis or severe liver impairment can reduce the body's ability to process tadalafil, leading to higher drug levels in the bloodstream and an increased risk of side effects. Kidney Disease: Severe kidney impairment: Kidney problems can affect how Tadaflo 5mg is eliminated from the body, potentially leading to higher concentrations of the drug and an increased risk of side effects. Retinal Disorders: Retinitis pigmentosa: This is a rare hereditary condition affecting the retina, and those with this disorder may be at higher risk for vision-related side effects, like sudden vision loss. Low Blood Pressure: Tadalafil may cause a temporary drop in blood pressure, which could be dangerous for people who already have low blood pressure or are on medications to lower blood pressure. Certain Medications: Nitrates: Tadalafil should not be used with nitrates (often prescribed for chest pain or angina) because the combination can cause a dangerous drop in blood pressure. Alpha-blockers: When used with medications for high blood pressure or BPH (e.g., doxazosin, tamsulosin), tadalafil can cause a significant drop in blood pressure. Peyronie’s Disease: While not a contraindication, people with Peyronie’s disease (a condition causing curvature of the penis) may not respond as well to tadalafil treatment, particularly if there are significant deformities or scarring. Always consult with a healthcare provider before starting Tadaflo 5 mg treatment, especially if you have any of these underlying conditions, as they may influence the safety and efficacy of the medication.